SCIENTIFIC PUBLICATIONS
Discover the scientific output of the researchers and groups that make up INTERGEN.
Alginate-encapsulated muscle-derived stem cell spheroids promote muscle regeneration in a murine model of volumetric muscle loss
Lucas Pari Mitre, Giovana Zanetti Ivanov, Shahin Shams, Fabio Yamaguchi, André Petraconi, Ricardo Jorge Espanhol Andrade, Eduardo Silva, Leonardo Martin and Roberta Sessa Stilhano
Stilhano's Laboratory - Santa Casa de São Paulo
Advancements in gene therapy for Wiskott–Aldrich syndrome: from early trials to emerging approaches
Luana de Mambro and Roberta Sessa Stilhano
Stilhano's Laboratory - Santa Casa de São Paulo
Landscape of ex vivo gene therapies: Technological trends and future prospects
Aline Almeida-Oliveira, Martín Hernán Bonamino, Marisol Simões, Vitor Hugo Villaça Martins, Diana Praia Borges Freire, Adriana Danowski, Thais Pereira Catão, Julianna do Nascimento e Silva Varela, Mariana Torres Mazzi, Carla Lemos Gottgtroy, Amanda de Miranda Marques, Monique Menegaci Barbosa and Beatriz de Castro Fialho
Cellular and gene immunotherapy - INCA
Location matters for brain gene therapy in lysosomal disorders
Guilherme Baldo
Gene therapy for rare diseases - UFRGS
Clinical trials to gene therapy development and production in Brazil: a review
Morales Saute, JA; Picanço-Castro, V.; De Freitas Lopes, AC; Da Silva Júnior, J. Batista; Henriques Nehm, J.; Dos Santos Maciel, F.; Doederlein Schwartz, IV; Ferraz Sallum, JM; Castro Ozelo, M.; Giugliani, R.; Bonamino, M.; Petrs-Silva, H.; Baldo, G.
Cellular and gene immunotherapy
An Overview about Biomarkers in Breast Cancer: Insights into the Diagnostic and Prognostic Significance
Santos, VEP; Franca Neto, PL; Isídio, Beatriz Eda De Oliveira; Fontes, PHB; Moura, IA; Cruz, Bruna Isabel Santos; De Sousa, Mylenna Máyra Gois; Santos, DL; Marcos, BFS; Pinho, SS; Bandeira, Beatriz Mendonça Alves; Leao, SL; Lima, TA; Invenção, Maria Da Conceição V.; Leal, LRS; Espinoza, BCF; Macedo, LS; Carvalho, MN; Silva Ajd; Freitas, AC; et al.
Molecular Studies and Experimental Therapy Group
Design and Immune Profile of Multi-Epitope Synthetic Antigen Vaccine against SARS-CoV-2: An In Silico and In Vivo Approach
Invention, M. da CV; Macêdo, LS de; Moura, IA de; Santos, LAB de O.; Espinoza, BCF; Pinho, SS de; Leal, LRS; Santos, DL dos; São Marcos, B. de FS; Elsztein, C.; Sousa, GF de; Souza-Silva, GA de; Barros, BR da S.; Cruz, LC de O.; Maux, JM de L.; Silva Neto, J. da CS; Melo, CML de; Silva, AJD; Batista, MV de A.; Freitas, AC de; et al.
Molecular Studies and Experimental Therapy Group
Topical delivery of siRNA to psoriatic skin model using high molecular weight chitosan derivatives: In vitro and in vivo studies
Martinez Junior, AM; Ruiz, TFR; Vilamaior, PSL; Tiera, O. VA; Taboga, SR; Tiera, M.J.
Biomaterials and Nanotechnology
The Controlled Release of Platelet-Rich Plasma–Loaded Alginate Repairs Muscle Damage With Less Fibrosis
Felipone, W.K.; de Mambro, L.; Ranieri, BR; Ivanov, GZ; Meves, R.; Martins, L. Stilhano, RS
Stilhano's Laboratory
Clinical trials to gene therapy development and production in Brazil: a review
Morales Saute, JA; Picanço-Castro, V.; de Freitas Lopes, AC; da Silva Júnior, JB; Henriques Nehm, J.; Dos Santos Maciel, F.; Doederlein Schwartz, IV; Ferraz Sallum, JM; Castro Ozelo, M.; Giugliani,, R.; Bonamino, M.; Petrs-Silva, H.; Baldo, G.
Gene therapy for rare diseases
Use of patient-derived organotypic tumor spheroids for testing of viral vector gene therapy in combination with checkpoint blockade
Domingues, A. C. M.; de Oliveira, S. B.; Tessarollo, N. G.; Lepique, A. P.; Rodrigues, O.; Sharova, T.; Lawless, A.; Li, D.; Basnet, M.; Boland, G. M.; Cohen, S.; Jenkins, R. W.; Strauss, B. E.
Laboratório de Vetores Virais
Influence of the degree of arginine substitution on chitosan-N-arginine-based chitosomes: Insights for improved gene delivery systems
Garcia, B.B.M., Mertins, O., da Silva, E.R. & Han, S.W.
Center for Research in Gene Therapy
In silico and in vivo analysis reveal impact of c-Myc tag in FMC63 scFv-CD19 protein interface and CAR-T cell efficacy
Lima, AJF; Hajdu, KL; Abdo, L.; Batista-Silva, LR; De Oliveira Andrade, C.; Correia, EM; Aragão, EAA; Bonamino, MH; Lourenzoni, MR
Cellular and gene immunotherapy
Protocol for the establishment of a serine integrase-based platform for functional validation of genetic switch controllers in eukaryotic cells
De Oliveira, MA; Florentino, LH; Sales, TT; Lima, RN; Barros, LRC; Limia, CG; Almeida, MSM; Robledo, ML; Barros, LMG; Melo, EO; Bittencourt, DM; Rehen, S.K.; Bonamino, MH; Rech, E.
Cellular and gene immunotherapy
Survival advantage of native and engineered T cells is acquired by mitochondrial transfer from mesenchymal stem cells.
Court, AC; Parra-Crisóstomo, E.; Castro-Córdova, P.; Abdo, L.; Aragão, EAA; Lorca, Rocío; F., Fernando E.; Bonamino, MH; Khoury, M.
Cellular and gene immunotherapy
Cell-Penetrating Peptides and CRISPR-Cas9: A Combined Strategy for Human Genetic Disease Therapy
Lira, C.; Correia, EM; Bonamino, M.; Vasconcelos, ZFM
Cellular and gene immunotherapy
Unveiling cross-reactivity: implications for immune response modulation in cancer
Pretti, MA M ; Vieira, GF; Boroni, M.; Bonamino, M.H.
Cellular and gene immunotherapy
AAV-Mediated Expression of miR-17 Enhances Neurite and Axon Regeneration In Vitro
Almeida RA, Ferreira CG, Matos VUS, Nogueira JM, Braga MP, Caldi Gomes L., Jorge EC, Soriani FM, Michel U., Ribas VTGene Therapy and Neurodegeneration Research Group
An overview on recent patents and technologies on nanoparticles for nucleic acid delivery
Dos Santos Fonseca, LM; Machado, BA S; Oliveira, FO; de Jesus Santos, JR; da Silva, JW; Hodel, KVS; Rosatti, BG; Pinto CD; Soares, MBP
Tissue Engineering and Immunopharmacology
Therapeutic applications of synthetic gene/genetic circuits: a patent review
Carneiro, DC; Rocha, VPC; Damasceno, PKF; Barbosa, JDV; Soares, MBP
Tissue Engineering and Immunopharmacology
Transplantation of autologous mesenchymal stromal cells in complete cervical spinal cord injury: a pilot study
Macêdo, CT; de Freitas Souza, BS; Villarreal, CF; Silva, DN; da Silva, KN; de Souza, CLEM; da Silva Paixão, D.; da Rocha Bezerra, M.; da Silva Moura Costa, AO; Brazão, ES; Marins Filho, JP; Matos, AC; dos Santos, RR; Soares, MBP
Tissue Engineering and Immunopharmacology
Different mechanisms guide the antinociceptive effect of bone marrow-mononuclear cells and bone marrow-mesenchymal stem/stromal cells in trigeminal neuralgia
Costa, CMM; Santos, DS; Opretzka, LCF; de Assis Silva, GS; Santos, GC; Evangelista, AF; Soares, MBP; Villarreal, CF
Tissue Engineering and Immunopharmacology
Mesenchymal stem cell-derived cell-free technologies: a patent landscape
Opretzka, LCF; Pinto, CD; Santos, JRJ; de Lima, AA; Soares, MBP; Villarreal, CF
Tissue Engineering and Immunopharmacology
A polyvalent RNA vaccine reduces the immune imprinting phenotype in mice and induces neutralizing antibodies against micron SARS-CoV-2
Costa Rocha, VP; Souza Machado, BA; Barreto, BC; Quadros, HC; Santana Fernandes, AM; Lima, EDS; Bandeira, ME; Meira, CS; Moraes dos Santos Fonseca, L.; Erasmus, J.; Khandhar, A.; Berglund, P.; Reed, S.; José da Silva Badaró, R. Pereira Soares, MB
Tissue Engineering and Immunopharmacology
Bovine papillomavirus vertical transmission: BPV diversity and expression in maternal and fetal tissues.
Pontes, NE; Carrazzoni, PG; Pessoa-Junior, ME; Tibúrcio Júnior, E.; Freitas, AC de; Silva, MAR da
Molecular Studies and Experimental Therapy Group
Immunological Response against Breast Lineage Cells Transfected with Human Papillomavirus (HPV).
Santos, DL; São Marcos, B. de F.; de Sousa, GF; Cruz, LC de O.; Barros, BR da S.; Nogueira, MC de BL; Oliveira, TH de A.; Silva, AJD; Santos, VEP; de Melo, CML; de Freitas, AC
Molecular Studies and Experimental Therapy Group
Identification and Functional Implications of the E5 Oncogene Polymorphisms of Human Papillomavirus Type 16
da Silva-Júnior, AHP; de Oliveira Silva, RC; Gurgel, APAD; Barros-Júnior, MR; Nascimento, KCG; Santos, DL; Pena, LJ; Lima, R. de CP; Batista, MV de A.; Chagas, BS; Freitas, AC de
Molecular Studies and Experimental Therapy Group
HPV Detection in Breast Tumors and Associated Risk Factors in Northeastern Brazil
Nascimento, KCG; São Marcos, B. de F.; Fontes, PHB; Isídio, BE de O.; Leão, SL; da Silva, GRP; Lussón, DB; dos Santos, DL; Leal, LRS; Espinoza, BC Flores; de Macêdo, LS; de França Neto, PL; Silva, AJD; Silva Neto, JC; Santos, VEP; de Freitas, AC
Molecular Studies and Experimental Therapy Group
Prolonged detection of BPV2 in urine and blood of papillomatosis-affected cattle not grazing bracken fern.
Tibúrcio-Júnior, E.; Carrazzoni, PG; Tenorio-Filho, F.; Pontes, NE; Alves, RV; de Freitas, AC; Silva, MAR
Molecular Studies and Experimental Therapy Group
Immune Response Modulation by HPV16 Oncoproteins in Lung Cancer: Insights from Clinical and In Vitro Investigations.
São Marcos, B. de F. ; Santos, DL dos ; Sousa, GF de ; Cruz, LC de O. ; Barros, BR da S. ; De Sena, MGAM ; Santos, VEP ; Oliveira, TH de A. ; Lagos De Melo, CM ; de Freitas, AC
Molecular Studies and Experimental Therapy Group
Pichia pastoris-Derived β-Glucan Capsules as a Delivery System for DNA Vaccines
Pinho, SS de; Invenção, M. da CV; Silva, AJD; Macêdo, LS de; Espinoza, BCF; Leal, LRS; da Gama, MAT M; Moura, I, A, de; Silva, ME dos S; Souza, DVS de; Lara, ML; Alves, JNSA; Freitas, AC de
Molecular Studies and Experimental Therapy Group
Tuning the surface charge and colloidal stability of hybrid gold-chitosan derivative nanoparticles for siRNA delivery
Martinez Júnior, AM; Aparecida De Oliveira Tiera, V.; José Tiera, M.
Biomaterials and Nanotechnology
Antiviral, anti-inflammatory and antioxidant effects of curcumin and curcuminoids in SH-SY5Y cells infected by SARS-CoV-2
Nicoliche, T.; Bartolomeo, CS; Lemes, RMR; Pereira, GC; Nunes, TA; Oliveira, RB; Nicastro, ALM; Soares, E. N.; da Cunha Lima, BF; Rodrigues, BM; Maricato, JT; Okuda, L.H.; from Sairre, MI; Prado, CM; Ureshino, R.P.; Stilhano, RS
Stilhano's Laboratory
Longitudinal evaluation of morphological, functional and vascular alterations in a rat model of experimental glaucoma
Araujo, VG; Alexandrino-Mattos, D. P;, Marinho, TP; Linden, R.; Petrs-Silva, H.
Laboratory of Gene Therapy and Viral Vectors
rAAV-compatible human mini promoters enhance transgene expression in rat retinal ganglion cells
Araujo, VG; Dias, MS; Hauswirth, W.W.; Linden, R.; Petrs-Silva, H.
Laboratory of Gene Therapy and Viral Vectors
Influence of size and crystallinity of nanohydroxyapatite (nHA) particles on the properties of Polylactic Acid/nHA nanocomposite scaffolds produced by 3D printing.
Rodovalho, AJRL; Barbosa, WT; Vieira, JL; from Oliva, CA; Gonçalves, APB; Cardoso, PSM; Modolon, HB; Montedo, ORK; Arcaro, S.; Hodel, KVS; Soares, MBP; Ajayan, PM; Barbosa, JDV
Tissue Engineering and Immunopharmacology
Stable expression of shRNA for the control of recombinant adenovirus replication
Lana, MVG; Antunes, F.; Tessarollo, NG; Strauss, B.E.
Viral Vector Laboratory
Induction of Immune-Stimulating Factors and Oncolysis Upon p14ARF Gene Transfer in Melanoma Cell Lines.
Mendonça, SA; Antunes, F.; Cerqueira, OLD; Del Valle, PR; Hunger, A.; Oliveira, PVS; Brito, B.; Costanzi-Strauss, E.; Strauss, BE
Viral Vector Laboratory
Ex vivo gene therapy for lysosomal storage disorders: future perspectives
Poletto, E.; Silva, AO; Weinlich, R.; Martin, P.K.M.; Torres, DC; Giugliani, R.; Baldo, G.
Gene therapy for rare diseases
Macrophages mobilized by the overexpression of the macrophage-colony stimulating factor promotes efficient recovery of ischemic muscle functionality
Gallo, CC, Honda, TSB, Alves, PT & Han, SW
Center for Research in Gene Therapy
Gelatin methacryloyl granular scaffolds for localized mRNA delivery
Carvalho, B. G.; Nakayama, A.; Miwa, H.; Han, S. W.; de la Torre, L. G.; Carlo, D. D.; Lee, J.; Kim, H.; Khademhosseini, A.; de Barros, N. R.
Centro de Investigação em Terapia Gênica
In-Hospital Manufacturing of Cellular Therapies Using Automated Systems
Kadauke, S.; Bonamino, M.; Levine, B.; Harrison, R.; Karnieli, O.
Cellular and gene immunotherapy
Implementation of a gene therapy education initiative by the ASGCT and Muhimbili University of Health and Allied Sciences
Cornetta, K.; Kay, S.; Urio, F.; Minja, I.K.; Mbugi, E.; Mgaya, J.; Mselle, T.; Nkya, S.; Alimohamed, MZ; Ndaki, K.; Bonamino, M.; Koya, R.C.; Shah, L. D.; Mahlangu, J.; Drago, D.; Rangarajan, S.; Jayandharan, G.R.
Cellular and gene immunotherapy
Shared Molecular Pathways in Glaucoma and Other Neurodegenerative Diseases: Insights from RNA-Seq Analysis and miRNA Regulation for Promising Therapeutic Avenues.
Vasconcelos, CFM; Ribas, VT; Petrs-Silva H.
Research Group on Gene Therapy and Neurodegeneration
Clinical Trials with Mesenchymal Stem Cell Therapies for Osteoarthritis: Challenges in the Regeneration of Joint Cartilage
Carneiro, DC; Araújo, LT; Santos, GC; Damasceno, PKF; Vieira, JL; Santos, RRD; Barbosa, JDV; Soares, MBP
Tissue Engineering and Immunopharmacology
Immunoinformatics applications in the development of therapeutic vaccines against human papillomavirus-related infections and cervical cancer.
Matos, AS; Invenção, M. da CV; Moura, IA de; Freitas, AC de ; Batista, MV de A.
Molecular Studies and Experimental Therapy Group
Whole Yeast Vaccine Displaying ZIKV B and T Cell Epitopes Induces Cellular Immune Responses in the Murine Model.
Silva, AJD; de Jesus, ALS; Leal, LRS; de Macêdo, LS; da Silva Barros, BR; de Sousa, GF; da Paz Leôncio Alves, S.; Pena, LJ; de Melo, CML; de Freitas, AC
Molecular Studies and Experimental Therapy Group
E7 Oncogene HPV58 Variants Detected in Northeast Brazil: Genetic and Functional Analysis
Chagas, BS; Tibúrcio Júnior, E.; Silva, RC de O.; Santos, DL dos; Barros Junior, MR; Lima, R. de CP de; Invenção, M. da CV; Santos, VEP; França Neto, PL; Silva Júnior, AH; Silva Neto, JC; Batista, MV de A.; Freitas, AC de
Molecular Studies and Experimental Therapy Group
RNA Vaccines: Yeast as a Novel Antigen Vehicle
Silva, AJD; de Sousa, MMG; de Macêdo, LS; França Neto, PL; Moura, IA de; Espinoza, BCF; Invenção, M. da CV; Pinho, SS; Gama, MATM; Freitas, A. C
Molecular Studies and Experimental Therapy Group
Advancing Immunotherapies for HPV-Related Cancers: Exploring Novel Vaccine Strategies and the Influence of Tumor Microenvironment
Silva, AJD; de Moura, IA; Gama, MATM; Leal, LRS; Pinho, SS; Espinoza, BCF; Santos, DL; Santos, VEP; Sena, MGAM; Invenção, M. da CV; de Macêdo, LS; França Neto, PL; Freitas, AC
Molecular Studies and Experimental Therapy Group
Long COVID: A Molecular, Cellular and Histopathology Overview.
da Silva Barros, BR; de Oliveira Cruz, LC; de Sousa, GF; Souza-Silva, GA; de Lima, MRCF; Oliveira, EG; Silva, AJD; Macêdo, LS; Leal, LRS; Marcos, BFS; Elsztein, C.; Invenção, M. da CV; de Freitas, AC; Moutinho-Melo, C.
Molecular Studies and Experimental Therapy Group
Disruptive 3D in vitro models for respiratory disease investigation: a state-of-the-art approach focused on SARS-CoV-2 infection
Seixas, ML; Bartolomeo, CS; Lemes, R.; Nicoliche, T.; Okuda, L.H.; Martins, L.; Ureshino, R.; Prado, CM; Liguori, TTA; Liguori, GR; Stilhano, RS
Stilhano's Laboratory
Tyrosine-Mutant AAV8 Vector Mediated Efficient and Safe Gene Transfer of Pigment Epithelium-Derived Factor to Mouse Lungs
Ferreira, DP; Martini, SV; Oliveira, HA; Silva, AL; Shenoy, S.; Chen, D.; Simon, V.; Han, E.; West, NE; Suk, J.S.; Rocco, PRM; Petrs-Silva, H.; Morales, MM; Cruz, F.F.
Laboratory of Gene Therapy and Viral Vectors
Potentiation of combined p19Arf and interferon-beta cancer gene therapy through its association with doxorubicin chemotherapy
Medrano, RFV; Salles, TA; Dariolli, R.; Antunes, F.; Feitosa, VA; Hunger, A.; Catani, JPP; Mendonça, SA; Tamura, RE; Lana, MG; Rodrigues, EG; Strauss, B.E.
Viral Vector Laboratory
Brain and visceral gene editing of mucopolysaccharidosis I mice by nasal delivery of the CRISPR/Cas9 system
Vera, LNP; Schuh, RS; Fachel, FNS; Poletto, E.; Piovesan, E.; Kubaski, F.; Couto, E.; Brum, B.; Rodrigues, G.; Souza, H.; Giugliani, R.; Matte, U.; Baldo, G.; Teixeira, H.F.
Gene therapy for rare diseases
Advanced microfluidic technologies for lipid nano-microsystems from synthesis to biological application.
Carvalho, B.; Ceccato, B.; Michelon, M.; Han, S.; de la Torre, L
Center for Research in Gene Therapy
Trends in hydrogel-based encapsulation technologies for advanced cell therapies applied to limb ischemia
Costa, ALR; Willerth, SM; de la Torre, LG; Han, S.W.
Center for Research in Gene Therapy
The ambiguous role of obesity in oncology by promoting cancer but boosting antitumor immunotherapy.
Assumpção, JAF; Pasquarelli-Do-Nascimento, G.; Duarte, MSV; Bonamino, MH; Magalhães, KG
Cellular and gene immunotherapy
Gene therapy access: Global challenges, opportunities, and views from Brazil, South Africa, and India
Cornetta, K.; Bonamino, MH; Mahlangu, J.; Mingozzi, F.; Rangarajan, S.; Rao, J.
Cellular and gene immunotherapy
CAR-T cell production
Preto De Godoy, J.; Bonamino, M.; Melo Alves Paiva, R.; Tiemi Kondo, A.; Keith Okamoto, O.; Nassif Kerbauy, L.
Cellular and gene immunotherapy
Preclinical studies using CAR-T cells
Preto De Godoy, J.; Nassif Kerbauy, L.; Melo Alves Paiva, R.; Tiemi Kondo, A.; Keith Okamoto, O.; Bonamino, M.
Cellular and gene immunotherapy
Oral Lichen Planus and Oral Squamous Cell Carcinoma share key oncogenic signatures
de Lanna, C. A.; Da Silva, B. N. M.; De Melo, A. C.; Bonamino, M. H.; Alves, L. D. B.; Pinto, L. F. R.; Cardoso, A. S.; Antunes, H. S.; Boroni, M.; Cohen Goldemberg, D.
Imunoterapia celular e gênica
The Role of Axonal Transport in Glaucoma
Dias, MS; Luo, X.; Ribas, VT; Petrs-Silva, H.; Koch, J.C.
Research Group on Gene Therapy and Neurodegeneration
Neuroprotective Gene Therapy by Overexpression of the Transcription Factor MAX in Rat Models of Glaucomatous Neurodegeneration
Lani-Louzada, R.; Marra, C.; Dias, MS; de Araújo, VG; Abreu, CA; Ribas, VT; Adesse, D.; Allodi, S.; Chiodo, V.; Hauswirth, W.; Petrs-Silva, H.; Linden, R.
Research Group on Gene Therapy and Neurodegeneration
Correlation between HPV PCNA, p16, and p21 Expression in Lung Cancer Patients
Marcos, BFS; de Oliveira, THA; do Amaral, CMM; Muniz, MTC; Freitas, AC
Molecular Studies and Experimental Therapy Group
Enhancing the Effect of Nucleic Acid Vaccines in the Treatment of HPV-Related Cancers: An Overview of Delivery Systems
de Moura, IA; Silva, AJD; de Macêdo, LS; Invenção, M. da CV; de Sousa, MMG; de Freitas, AC
Molecular Studies and Experimental Therapy Group
Third-Generation Vaccines: Features of Nucleic Acid Vaccines and Strategies to Improve Their Efficiency
Melo, AR da S.; de Macêdo, LS; Invenção, M. da CV; de Moura, IA; da Gama, MATM; de Melo, C. . L.; Silva, AJD; Batista, MV de A.; Freitas, AC de
Molecular Studies and Experimental Therapy Group
Standardization and Key Aspects of the Development of Whole Yeast Cell Vaccines
Silva, AJD; Rocha, CK da S.; de Freitas, AC
Molecular Studies and Experimental Therapy Group
Double-grafted chitosans as siRNA nanocarriers: effects of diisopropylethylamine substitution and labile-PEG coating
Martinez Junior, AM; de Souza, RHFV; Petrônio, MS; Martins, GO; Fernandes, JC; Benderdour, M.; Tiera, VAO de; Tiera, M.J.
Biomaterials and Nanotechnology
Unraveling Muscle Impairment Associated With COVID-19 and the Role of 3D Culture in Its Investigation
Seixas, MLGA; Mitre, LP; Shams, S.; Lanzuolo, GB; Bartolomeo, CS; Silva, EA; Prado, CM; Ureshino, R.; Stilhano, RS
Stilhano's Laboratory
Neuroprotective Gene Therapy by Overexpression of the Transcription Factor MAX in Rat Models of Glaucomatous Neurodegeneration
Lani-Louzada, R.; Marra, C.; Dias, MS; de Araújo, VG; Abreu, CA; Ribas, VT; Adesse, D.; Allodi, S.; Chiodo, V.; Hauswirth, W.; Petrs-Silva, H.; Linden, R.
Laboratory of Gene Therapy and Viral Vectors
Analyzes of the pericyte transcriptome in ischemic skeletal muscles
Teng, Y.C.; Porfírio-Sousa, AL; Ribeiro, GM; Arend, MC; da Silva Meirelles, L.; Chen, ES; Rosa, DS; Han, S.W.
Center for Research in Gene Therapy
Adjuvant properties of IFN-γ and GM-CSF in the scFv6.C4 DNA vaccine against CEA-expressing tumors
Zanetti, BF, Ferreira, CP, de Vasconcelos, JRC & Han, S. W
Center for Research in Gene Therapy
Regenerative effect of platelet-rich plasma in murine ischemic limbs.
Stilhano, RS; Denapoli, PMA; Gallo, CC; Samoto, V.Y.; Ingham, S.J.M.; Abdalla, RJ; Koh, T.J.; Han, S.W.
Center for Research in Gene Therapy
Structural determinants of chimeric antigen receptor design
Abdo, L.; Aragao, E.A.; Bonamino, M.
Cellular and gene immunotherapy
Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms
Secardin, L.; Clean, CG; Silva-Benedito, S.; Lordier, L.; El-Khoury, M.; Marty, C.; Ianotto, J.; Raslova, H.; Constantinescu, SN; Bonamino, MH; Vainchenker, W.; Monte-Mor, B.; Stefano, A.; Plo, I.
Cellular and gene immunotherapy
Brazilian Association of Hematology, Hemotherapy and Cell Therapy Consensus on genetically modified cells. VII. Present and future of technologies for production of CAR cell therapies
Ramos, RN; Picanço-Castro, V.; Oliveira, TGM; Mendrone, A.; De Santis, GC; Bonamino, MH; Rocha, V.
Cellular and gene immunotherapy
Brazilian Association of Hematology, Hemotherapy and Cell Therapy Consensus on genetically modified cells. VIII: CAR-T cells: preclinical development - Safety and efficacy evaluation
Picanço-Castro, V.; Bonamino, MH; Ramos, RN; Guerino-Cunha, RL; Oliveira, TGM; Rego, EM
Cellular and gene immunotherapy
The prevalence and prognostic impact of tumor-infiltrating lymphocytes in uterine carcinosarcoma
da Silva, JL; from Albuquerque, LZ; Rodrigues, FR; de Mesquita, GG; Chaves, CBP; Bonamino, MH; De Melo, AC
Cellular and gene immunotherapy
AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo.
Ribas, VT; Vahsen, B.F.; Tatenhorst, L.; Estrada, V.; Dambeck, V.; Almeida, RA; Bähr, M.; Michel, U.; Koch, J.C.; Müller, HW; Lingor, P.
Research Group on Gene Therapy and Neurodegeneration
Yeasts as a promising delivery platform for DNA and RNA vaccines.
Silva, AJD; de Macêdo, LS; Leal, LRS; de Jesus, ALS; Freitas, A.C.
Molecular Studies and Experimental Therapy Group
Pichia pastoris displaying ZIKV protein epitopes from the Envelope and NS1 induce in vitro immune activation
Silva, AJD; Jesus, ALS; Leal, LRS; Silva, GAS; Melo, CML; Freitas, AC
Molecular Studies and Experimental Therapy Group
EntroPhylo: An entropy-based tool to select phylogenetic informative regions and primer design
Santos, FLSG; Paiva Júnior, SSL; Freitas, AC; Balbino, VQ; Batista, MVA
Molecular Studies and Experimental Therapy Group
Detection of Human Papillomavirus DNA in Paired Peripheral Blood and Cervix Samples in Patients with Cervical Lesions and Healthy Individuals
do Nascimento, KCG; de Lima, É. G.; da Mota Nunes, Z.; Barros, Ma. R.; de Aragão Batista, MV; Lucena-Araújo, AR; da Costa Silva Neto, J.; Chagas, BS; Gurgel, APAD; de Freitas, AC
Molecular Studies and Experimental Therapy Group
Development of synthetic antigen vaccines for COVID-19
Viana Invenção, M. da C.; Melo, AR da S.; de Macêdo, LS; da Costa Neves, TSP; de Melo, CML; Cordeiro, MN; de Aragão Batista, MV; de Freitas, AC
Molecular Studies and Experimental Therapy Group
Combination of cabazitaxel and p53 gene therapy abolishes prostate carcinoma tumor growth
Tamura, RE; Lana, MG; Costanzi-Strauss E.; Strauss, B.E.
Viral Vector Laboratory
Arginine-modified chitosan complexed with liposome systems for plasmid DNA delivery
Garcia, BBM; Mertins, O.; da Silva, ER; Mathews, PD; Han, S.W.
Center for Research in Gene Therapy
Transposon-mediated generation of CAR-T cells shows efficient anti B cell leukemia response after ex vivo expansion
Chicaybam, L.; Abdo, L.; Viegas, M.; Marques, LVC; Sousa, P.; Batista-Silva, L.; Alves-Monteiro, I.; Bonecker, S.; Monte-Mor, B.; Bonamino, Martin H.
Cellular and gene immunotherapy
Poor clinical outcome in metastatic melanoma is associated with a microRNA-modulated immunosuppressive tumor microenvironment
Jorge, NAN; Cruz, JGV; Pretti, MAM; Bonamino, MH; Possik, PA; Boroni, M.
Cellular and gene immunotherapy
TET2 haploinsufficiency alters reprogramming into induced pluripotent stem cells
Secardin, L.; Limia, CEG; Stefano, A.; Bonamino, Mh; Saliba, J.; Kataoka, K.; Rehen, S.K.; Raslova, H.; Marty, C.; Ogawa, S.; Vainchenker, W. ; Monte-Mor, BCR; Plo, I.
Cellular and gene immunotherapy
Development of CAR-T cell therapy for B-ALL using a point-of-care approach.
Abdo, L. ; Barros, L. R. C. ; Viegas, M. S. ; Marques, L. V. C. ; Ferreira, P. S. ; Chicaybam, L. ; Bonamino, M. H .
Imunoterapia celular e gênica
Does the sequence of anthracycline and taxane matter? The NeoSAMBA trial.
Bines, J.; Small, I.; Sarmento, R.; Kestelman, F.; Silva, S.; Rodrigues, F.; Faroni, L.; Goncalves, A.; Ebecken, E. ; Maroun, P.; Millen, E.; Bonamino, M.
Cellular and gene immunotherapy
Genetic switches designed for eukaryotic cells and controlled by serine integrases.
Gomide, MS; Sales, TT; Barros, LR; Limia, CG; Oliveira, MA; Florentino, LH; Barros, LM; Robledo, ML; Jose, GP; Almeida, MS; Lima, RN; Rehen, SK; Lacorte, C.; Melo, EO; Murad, AM; Bonamino, MH; Coelho, CM; Rech, E.
Cellular and gene immunotherapy
High infiltration of B cells in tertiary lymphoid structures, TCR oligoclonality, and neoantigens are part of esophageal squamous cell carcinoma microenvironment.
Barros, LR; Santos, PTD; Pretti, MAM; Vieira, GF; Bragatte, MA; Resende, MFD; Freitas, MV; Scherer, ND; Oliveira, IM; Rapozo, DCM; Fernandes, PV; Simao, TD; Lima, SC; Boroni, MM; Pinto, LFR; Bonamino, M.H.
Cellular and gene immunotherapy
Overhauling CAR T cells to improve efficacy, safety and cost
Chicaybam, L.; Bonamino, M; Invitti, A.; Rozenchan, P.; Luna, I.; Strauss, B.
Cellular and gene immunotherapy
Senolytic chimeric antigen receptor (CAR) T cell: Driving the immune system to fight cell senescence
Hajdu, KL; Bonamino, M. H.
Cellular and gene immunotherapy
Human mesenchymal stromal/stem cells recruit resident pericytes and induce blood vessel maturation to repair experimental spinal cord injury in rats.
Menezes, K.; Rosa, BG; Freitas, C.; Cruz, AS; Santos, RS; Nascimento, MA; Alves, DVL; Bonamino, MH; Rossi, MI; Borojevic, R.; Coelho-Sampaio, T
Cellular and gene immunotherapy
CAR-T cells leave the comfort zone: current and future applications beyond cancer
Mazzi, MT; Hajdu, KL; Ribeiro, PR; Bonamino, M.H.
Cellular and gene immunotherapy
Class I HLA Allele Predicted Restricted Antigenic Coverages for Spike and Nucleocapsid Proteins Are Associated With Deaths Related to COVID-19
Pretti, MAM; Galvani, RG; Vieira, GF; Bonomo, AC; Bonamino, MH; Boroni, M.
Cellular and gene immunotherapy
Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicing
Vahsen, B.F.; Ribas, VT; Sundermeyer, J.; Boecker, A.; Dambeck, V.; Lenz, C.; Shomroni, O.; Caldi Gomes, L.; Tatenhorst, L.; Barski, E.; Roser, A.E.; Michel, U.; Urlaub, H.; Salinas, G.; Bähr, M.; Koch, J.C.; Lingor, P.
Research Group on Gene Therapy and Neurodegeneration
AAV-Mediated Expression of Dominant-Negative ULK1 Increases Neuronal Survival and Enhances Motor Performance in the MPTP Mouse Model of Parkinson's Disease
Balke, D.; Tatenhorst, L.; Dambeck, V.; Ribas, VT; Vahsen, B.F.; Michel, U.; Bähr, M.; Lingor, P.
Research Group on Gene Therapy and Neurodegeneration